比如，和誉医药的第二代FGFR小分子抑制剂ABSK061，在降低对FGFR1抑制的同时，保持对FGFR2/3高选择性，理论上安全性更高。在动物模型中，ABSK061的表现优于Infigratinib，目前ABSK061治疗3-12岁ACH儿童患者的2期临床正在进行中。
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Just down the corridor from my room, the door opened to a view of the scattered sheds that gave this side of the station a feeling of sprawl. It’s nothing like the scar on the continent that is McMurdo, but with the booze shack, hazardous-waste storage, weather-balloon-and-meteorology headquarters, ski-equipment storage, and gym, to name a few, the area wasn’t exactly tidy. I paused to watch a bulldozer pushing snow away from the building, emitting billowing clouds of exhaust into some of the cleanest air on earth.